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Rifampin

Brand: Rifadin

Rifamycin antibioticUsed for: Tuberculosis, meningococcal prophylaxisAnti-Infectives

No boxed warning on the current FDA label.

Caution
Liver injury; powerful enzyme induction lowers many drug levels; body fluids turn orange-red.

Common side effects

  • Harmless orange-red discoloration of urine, sweat, and tears
  • Nausea
  • Elevated liver enzymes
  • Rash

Key interactions

  • Powerful enzyme inducer: lowers contraceptive, warfarin, and many other drug levels
  • Reduces the effect of DOACs

Counseling points

  • Body fluids turn orange-red; soft contact lenses stain permanently
  • Use a non-hormonal backup contraceptive during therapy
  • Take on an empty stomach
  • Liver function is monitored
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