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Penicillin

Brand: Penicillin VK (oral), Bicillin L-A (injection)

Penicillin antibioticUsed for: Strep throat, syphilis, dental infectionsAnti-Infectives
Boxed warning

Bicillin L-A and C-R only: not for intravenous use, because inadvertent IV injection has caused cardiorespiratory arrest and death; oral penicillin V carries no boxed warning.

Caution
True penicillin allergy can be life-threatening; cephalosporins share the beta-lactam ring and carry a small cross-reactivity risk.
Storage
Reconstituted penicillin V suspension: refrigerate and discard after 14 days; Bicillin L-A syringes are refrigerated.

Common side effects

  • Diarrhea
  • Nausea
  • Rash
  • Allergic reaction

Key interactions

  • Probenecid raises its level

Counseling points

  • Take on an empty stomach for best absorption
  • Report rash, hives, or trouble breathing at once
  • Complete the full course even once you feel better
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