Pioglitazone
Brand: Actos
Boxed warning · ISMP high-alert drug
Causes or worsens congestive heart failure; contraindicated in NYHA class III or IV heart failure.
- Caution
- Bladder cancer risk with long use, fluid retention, and fractures in women.
Common side effects
- Fluid retention and swelling
- Weight gain
- Bone fracture risk
- Anemia
Key interactions
- Additive fluid retention with insulin
- Strong CYP2C8 inhibitors raise its level
Counseling points
- Report rapid weight gain, ankle swelling, or breathlessness
- Takes weeks for full effect
- Regular eye exams are advised
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