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Phenytoin

Brand: Dilantin, Phenytek

AnticonvulsantUsed for: SeizuresCNS & Psychiatric

No boxed warning on the current FDA label.

Caution
Narrow therapeutic index; injection given too fast causes severe hypotension and arrhythmias (the injection carries a boxed warning, the oral forms do not).
Pregnancy
Avoid if possible: fetal hydantoin syndrome (birth defects).

Common side effects

  • Overgrowth of the gums
  • Unsteadiness and slurred speech
  • Involuntary eye movement
  • Rash

Key interactions

  • Induces liver enzymes: lowers contraceptive and warfarin levels
  • Tube feeds reduce absorption
  • Many drugs shift its free level

Counseling points

  • Good oral hygiene reduces gum overgrowth
  • Blood levels are followed closely
  • Report rash, unsteadiness, or slurred speech
  • Do not switch between brands without advice
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