Phenelzine
Brand: Nardil
Boxed warning
Suicidal thoughts and behaviors in children, adolescents, and young adults.
- Caution
- Hypertensive crisis with tyramine-rich foods and sympathomimetics; 2-week washout when switching antidepressants.
Common side effects
- Dizziness on standing
- Insomnia
- Weight gain
- Sexual side effects
Key interactions
- Tyramine-rich foods can cause a hypertensive crisis
- Contraindicated with SSRIs, SNRIs, triptans, and linezolid
- Decongestants such as pseudoephedrine can spike blood pressure
- Dextromethorphan is contraindicated
Counseling points
- Avoid aged cheese, cured meats, tap beer, and fermented foods
- Avoid all over-the-counter cold and cough products without checking
- Report severe headache, chest pain, or a racing heart immediately
- A 2-week washout is needed when switching antidepressants
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