Paroxetine
Brand: Paxil, Paxil CR (Pexeva discontinued)
Boxed warning
Suicidal thoughts and behaviors in children, adolescents, and young adults.
- Caution
- Marked discontinuation syndrome on abrupt stopping; reduces tamoxifen activation.
- Pregnancy
- Avoid in pregnancy: first-trimester exposure is linked to cardiac malformations.
Common side effects
- Sexual side effects
- Weight gain
- Drowsiness
- Nausea
Key interactions
- Contraindicated with MAO inhibitors
- Reduces tamoxifen's effectiveness
- Serotonin syndrome risk with triptans and tramadol
Counseling points
- Do not stop abruptly. This drug has a marked discontinuation syndrome
- Full effect takes 4 to 6 weeks
- Report agitation or worsening mood early in treatment
- Tell the pharmacist if you are pregnant or planning a pregnancy
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