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Modafinil

Brand: Provigil

Wakefulness-promoting agent (C-IV)Used for: Narcolepsy, shift-work sleepinessCNS & Psychiatric

No boxed warning on the current FDA label.

Caution
Serious rash including Stevens-Johnson syndrome; reduces hormonal contraceptive effectiveness.

Common side effects

  • Headache
  • Nausea
  • Anxiety
  • Insomnia

Key interactions

  • Reduces the effectiveness of hormonal contraceptives
  • Induces liver enzymes, lowering other drug levels

Counseling points

  • Take in the morning to avoid disturbing sleep
  • Use a backup contraceptive method during and for a month after
  • Report any rash immediately
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