← Drug quick-reference

Ondansetron

Brand: Zofran

Antiemetic (5-HT3 blocker)Used for: Nausea and vomitingGastrointestinal

No boxed warning on the current FDA label.

Caution
QT prolongation and torsades; serotonin syndrome with serotonergic drugs; the 32 mg single IV dose was withdrawn.

Common side effects

  • Headache
  • Constipation
  • Fatigue
  • Dizziness
  • Diarrhea

Key interactions

  • Serotonin syndrome risk with serotonergic drugs
  • Can prolong the heart's QT interval
  • Caution with other QT-prolonging drugs
  • Apomorphine combination causes severe low blood pressure

Counseling points

  • May take with or without food
  • Let orally disintegrating tablet dissolve on tongue
  • Report irregular or fast heartbeat
  • Report constipation
  • Use as directed for nausea
We ask 9 questions about Ondansetron.Practice Ondansetron →Test yourself on medications like Ondansetron.Practice Medications →
← OmeprazolePantoprazole →

High-yield study aid for exam prep, not a substitute for the package insert or a pharmacist’s dispensing reference.