Omeprazole
Brand: Prilosec
No boxed warning on the current FDA label.
- Caution
- Long-term use is linked to C. difficile infection, low magnesium, B12 deficiency, and fractures; reduces clopidogrel activation.
Common side effects
- Headache
- Diarrhea
- Stomach pain
- Nausea
- Gas
Key interactions
- Reduces effect of clopidogrel
- May reduce absorption of some drugs needing acid
- May increase certain drug levels
- Long-term use may lower magnesium
Counseling points
- Take before a meal, usually morning
- Swallow capsule whole; do not crush
- May take 1-4 days for full relief
- Report ongoing use beyond directed time
- Long-term use may affect magnesium or B12
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