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Pantoprazole

Brand: Protonix

Proton pump inhibitorUsed for: GERDGastrointestinal

No boxed warning on the current FDA label.

Caution
Long-term use is linked to C. difficile infection, low magnesium, B12 deficiency, and fractures.

Common side effects

  • Headache
  • Diarrhea
  • Nausea
  • Stomach pain
  • Gas

Key interactions

  • Reduces absorption of some drugs needing acid
  • May raise bleeding risk with warfarin
  • Methotrexate levels may rise with high-dose methotrexate

Counseling points

  • Take before a meal, often in the morning
  • Do not crush delayed-release tablets
  • Report ongoing diarrhea
  • Long-term use may need monitoring
  • Report unexpected bone fractures
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