Metoclopramide
Brand: Reglan
Boxed warning
Tardive dyskinesia, which may be irreversible; avoid treatment longer than 12 weeks.
- Caution
- Contraindicated with GI obstruction, pheochromocytoma, or seizure disorder; depression and neuroleptic malignant syndrome.
Common side effects
- Drowsiness
- Restlessness
- Tardive dyskinesia
- Diarrhea
Key interactions
- Additive sedation with CNS depressants
- Antipsychotics add movement-disorder risk
- Opposes the effect of dopamine agonists
Counseling points
- Report involuntary movements of the face, tongue, or limbs at once
- Usually taken before meals and at bedtime
- Avoid alcohol
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