Methimazole
Brand: Tapazole
No boxed warning on the current FDA label.
- Caution
- Agranulocytosis: report fever or sore throat at once; liver injury.
- Pregnancy
- Avoid in the first trimester: birth defects (aplasia cutis, choanal atresia); propylthiouracil is preferred then and methimazole after.
Common side effects
- Rash
- Joint pain
- Low white cell count
- Altered taste
Key interactions
- Reduces the required warfarin dose as thyroid function normalizes
Counseling points
- Report fever or sore throat: it can signal a low white cell count
- Thyroid function is checked regularly
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