Linezolid
Brand: Zyvox
No boxed warning on the current FDA label.
- Caution
- Myelosuppression with courses over 2 weeks; serotonin syndrome with serotonergic drugs because it inhibits MAO.
Common side effects
- Diarrhea
- Headache
- Low platelet count
- Peripheral neuropathy with long use
Key interactions
- Also inhibits monoamine oxidase: serotonin syndrome risk with SSRIs, SNRIs, and triptans
- Tyramine-rich foods can raise blood pressure
Counseling points
- Tell the prescriber about every antidepressant you take
- Limit aged cheese and cured meats
- Blood counts are checked with longer courses
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