← Drug quick-reference

Letrozole

Brand: Femara

Aromatase inhibitorUsed for: Hormone-receptor-positive breast cancerOther High-Yield

No boxed warning on the current FDA label.

Caution
Bone loss and fractures; joint pain; only for postmenopausal women.
Pregnancy
Contraindicated in pregnancy: fetal harm.

Common side effects

  • Hot flashes
  • Joint pain
  • Bone thinning
  • Fatigue

Key interactions

  • Estrogen-containing products oppose its effect

Counseling points

  • Joint pain is common: report it if it limits daily activity
  • Bone density is monitored
  • Only for postmenopausal women
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