Leucovorin
Brand: (no brand; generic only)
No boxed warning on the current FDA label.
- Caution
- Never give intrathecally; do not confuse with folic acid, and dose timing relative to methotrexate is critical.
Common side effects
- Rash
- Nausea
- Rarely, allergic reaction
Key interactions
- Given deliberately WITH methotrexate to protect healthy cells
- High doses reduce the antiseizure effect of phenytoin and phenobarbital
Counseling points
- Timing matters: doses are scheduled relative to the methotrexate dose
- Never skip or delay a rescue dose
- Do not confuse with folic acid supplementation
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