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Hydroxychloroquine

Brand: Plaquenil

Antimalarial / DMARDUsed for: Lupus, rheumatoid arthritis, malariaAnti-Infectives

No boxed warning on the current FDA label.

Caution
Irreversible retinal damage with long-term use: baseline and periodic eye exams are required; QT prolongation.

Common side effects

  • Nausea
  • Headache
  • Retinal toxicity with long use
  • Rash

Key interactions

  • Additive QT risk with other QT-prolonging drugs
  • Raises digoxin levels
  • Antacids reduce absorption

Counseling points

  • Baseline and periodic retinal eye exams are required
  • Take with food to reduce stomach upset
  • Report vision changes promptly
  • Full effect can take months
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