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Hydrochlorothiazide

Brand: Microzide (discontinued; generic only)

Thiazide diureticUsed for: High blood pressure, edemaCardiovascular

No boxed warning on the current FDA label.

Caution
Low potassium and sodium, and raised uric acid, blood sugar, and calcium; contraindicated with sulfonamide allergy on some labels.

Common side effects

  • Increased urination
  • Low potassium
  • Dizziness
  • Elevated blood sugar
  • Elevated uric acid

Key interactions

  • NSAIDs reduce its effect
  • May raise lithium levels
  • Adds to other blood-pressure lowering drugs
  • May worsen blood sugar control

Counseling points

  • Take in the morning to avoid nighttime urination
  • Rise slowly to reduce dizziness
  • Report muscle cramps or weakness
  • Use sunscreen for sun sensitivity
  • Report severe rash or gout flare
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