Heparin
Brand: (no brand; generic only)
No boxed warning on the current FDA label. On the ISMP high-alert list.
- Caution
- The 10 units/mL flush and 10,000 units/mL vials look alike and mix-ups have caused fatal overdoses; heparin-induced thrombocytopenia can occur.
- Storage
- Room temperature; store the flush strength and the high-concentration vials apart.
Common side effects
- Bleeding and easy bruising
- Low platelet count (HIT)
- Injection-site irritation
- Elevated liver enzymes
Key interactions
- Additive bleeding risk with NSAIDs, aspirin, and other anticoagulants
- Reversed by protamine sulfate
Counseling points
- Report unusual bruising, black stools, or pink urine
- Monitored with aPTT, not INR
- Use a soft toothbrush and an electric razor
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