← Drug quick-reference

Clonidine

Brand: Catapres-TTS (patch); Catapres tablets and Kapvay discontinued (generic)

Alpha-2 agonistUsed for: High blood pressure, ADHDCardiovascular

No boxed warning on the current FDA label.

Caution
Abrupt discontinuation causes rebound hypertension; clonidine and clonazepam are an ISMP confused-name pair.

Common side effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Constipation

Key interactions

  • Additive sedation with CNS depressants
  • Beta blockers worsen rebound hypertension on withdrawal
  • Tricyclics reduce its effect

Counseling points

  • Never stop abruptly: rebound high blood pressure can be severe
  • Rise slowly from sitting or lying
  • Rotate patch sites weekly if using the transdermal form
  • Easily confused with clonazepam: check the label carefully
We ask 6 questions about Clonidine.Practice Clonidine →Test yourself on medications like Clonidine.Practice Medications →

High-yield study aid for exam prep, not a substitute for the package insert or a pharmacist’s dispensing reference.