Chlorthalidone
Brand: Thalitone
No boxed warning on the current FDA label.
- Caution
- Low potassium is the key risk and it makes digoxin toxicity more likely.
Common side effects
- Low potassium
- Increased urination
- Dizziness on standing
- Raised blood sugar
- Raised uric acid
Key interactions
- Digoxin toxicity risk if potassium falls
- Lithium levels rise
- NSAIDs blunt the blood-pressure effect
- Adds to other blood-pressure drugs
Counseling points
- Take in the morning so you are not up overnight
- It works longer than hydrochlorothiazide
- Report muscle cramps or weakness: they can signal low potassium
- Rise slowly to avoid dizziness
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