Clopidogrel
Brand: Plavix
Boxed warning
Diminished antiplatelet effect in CYP2C19 poor metabolizers (two loss-of-function alleles).
- Caution
- Bleeding risk, and thrombotic thrombocytopenic purpura (rare); omeprazole and esomeprazole reduce its activation.
Common side effects
- Easy bruising
- Bleeding
- Diarrhea
- Rash
Key interactions
- Omeprazole may reduce its effect
- Adds bleeding risk with NSAIDs and other blood thinners
- Caution with aspirin
Counseling points
- Take at the same time each day
- Report unusual bleeding or bruising
- Tell dentists and surgeons before procedures
- Do not stop without talking to prescriber
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High-yield study aid for exam prep, not a substitute for the package insert or a pharmacist’s dispensing reference.