Allopurinol
Brand: Zyloprim
No boxed warning on the current FDA label.
- Caution
- Severe skin reactions (Stevens-Johnson syndrome, DRESS), highest risk with the HLA-B*5801 allele and kidney impairment; stop at the first sign of rash.
Common side effects
- Rash
- Nausea
- Gout flare when starting
- Drowsiness
- Diarrhea
Key interactions
- Raises levels of azathioprine and mercaptopurine
- May increase warfarin effect
- Caution with ampicillin (rash)
- Thiazide diuretics raise the risk of hypersensitivity reactions
Counseling points
- Take after meals to reduce stomach upset
- Drink plenty of water
- Does not treat an active gout attack
- Stop and report any skin rash
- Keep taking even during a flare
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