Tizanidine
Brand: Zanaflex
No boxed warning on the current FDA label.
- Caution
- Contraindicated with ciprofloxacin or fluvoxamine (severe hypotension); liver injury, so liver enzymes are monitored.
Common side effects
- Drowsiness
- Dry mouth
- Low blood pressure
- Weakness
Key interactions
- Ciprofloxacin and fluvoxamine sharply raise its level: contraindicated
- Additive sedation with CNS depressants
- Alcohol increases sedation
Counseling points
- Do not switch between tablets and capsules without advice. They behave differently with food
- Rise slowly
- Do not stop abruptly after long use
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