Ticagrelor
Brand: Brilinta
Boxed warning
Significant, sometimes fatal bleeding; aspirin above 100 mg daily reduces its effectiveness.
- Caution
- Dyspnea is common; contraindicated with a history of intracranial hemorrhage.
Common side effects
- Bleeding and bruising
- Shortness of breath
- Slow heartbeat
- Headache
Key interactions
- Aspirin doses above 100 mg per day reduce its effectiveness
- Strong CYP3A4 inhibitors raise its level
- Additive bleeding risk with anticoagulants
Counseling points
- Take twice daily, with low-dose aspirin only
- Breathlessness is common and usually harmless: report if severe
- Do not stop without speaking to the prescriber
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