Spironolactone
Brand: Aldactone
No boxed warning on the current FDA label.
- Caution
- Dangerous high potassium, especially with ACE inhibitors, ARBs, potassium supplements, or salt substitutes.
- Pregnancy
- Avoid in pregnancy: anti-androgen effects on a male fetus.
Common side effects
- Elevated potassium
- Breast tenderness or enlargement
- Dizziness
- Menstrual changes
- Increased urination
Key interactions
- Avoid potassium supplements and salt substitutes
- ACE inhibitors and ARBs raise potassium further
- NSAIDs may reduce its effect
- Caution with other potassium-sparing diuretics
Counseling points
- Take with food to reduce stomach upset
- Limit high-potassium foods and salt substitutes
- Report muscle weakness or irregular heartbeat
- Rise slowly to reduce dizziness
- Have potassium and kidney labs monitored
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