Spironolactone
Brand: Aldactone
Key warning
High-alert caution: can cause dangerously high potassium, especially with ACE inhibitors, ARBs, potassium supplements or salt substitutes. Note current Aldactone labeling carries NO boxed warning — the old tumorigen-in-rats text was moved to Nonclinical Toxicology, though some older generic labels still show the retired box.
Common side effects
- Elevated potassium
- Breast tenderness or enlargement
- Dizziness
- Menstrual changes
- Increased urination
Key interactions & cautions
- Avoid potassium supplements and salt substitutes
- ACE inhibitors and ARBs raise potassium further
- NSAIDs may reduce its effect
- Caution with other potassium-sparing diuretics
Counseling points
- Take with food to reduce stomach upset
- Limit high-potassium foods and salt substitutes
- Report muscle weakness or irregular heartbeat
- Rise slowly to reduce dizziness
- Have potassium and kidney labs monitored
High-yield study aid for exam prep — not a substitute for the package insert or a pharmacist’s dispensing reference.