Rosuvastatin
Brand: Crestor
No boxed warning on the current FDA label.
- Caution
- Muscle pain and rare rhabdomyolysis; Asian patients start at lower doses because blood levels run higher.
- Pregnancy
- Generally avoid in pregnancy: no benefit to the fetus and stopping is recommended for most patients.
Common side effects
- Muscle aches
- Headache
- Nausea
- Weakness
Key interactions
- Certain drugs (e.g., cyclosporine, gemfibrozil) raise muscle-damage risk
- Separate from aluminum/magnesium antacids by 2 hours
- May increase warfarin (INR) effect
Counseling points
- May take at any time of day
- Report unexplained muscle pain or weakness
- Report dark urine
- Continue a heart-healthy diet
- Avoid alcohol excess
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