Morphine
Brand: MS Contin
Boxed warning · ISMP high-alert drug
Addiction, abuse, and misuse; life-threatening respiratory depression; profound sedation and death with benzodiazepines or other CNS depressants; neonatal opioid withdrawal syndrome with prolonged use in pregnancy.
- Caution
- Extended-release products must not be crushed, chewed, or dissolved.
- Pregnancy
- Prolonged use in pregnancy causes neonatal opioid withdrawal syndrome (boxed).
Common side effects
- Constipation
- Drowsiness
- Nausea
- Slowed breathing
- Itching
Key interactions
- Dangerous sedation with benzodiazepines
- Adds to alcohol and other sedatives
- Avoid MAO inhibitors
Counseling points
- May impair driving
- Avoid alcohol
- Use a stool softener for constipation
- Swallow extended-release whole, do not crush
- Controlled substance, store securely
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