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Flumazenil

Brand: (no brand; generic only)

Benzodiazepine antagonistUsed for: Reversal of benzodiazepine sedationOther High-Yield
Boxed warning

Seizures, most often in patients on long-term benzodiazepines or in mixed overdoses with tricyclic antidepressants.

Caution
Resedation can occur because flumazenil is shorter-acting than most benzodiazepines; monitor for at least 2 hours.

Common side effects

  • Agitation
  • Dizziness
  • Nausea and vomiting
  • Seizures

Key interactions

  • Reverses only benzodiazepines: no effect on opioids
  • Risk of seizure rises with tricyclic antidepressant overdose

Counseling points

  • Shorter-acting than many benzodiazepines, so sedation can return
  • Used in a monitored setting only
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