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Dutasteride

Brand: Avodart

5-alpha reductase inhibitorUsed for: Enlarged prostate (BPH)Other High-Yield

No boxed warning on the current FDA label.

Caution
Pregnant women should not handle leaking capsules: absorbed drug can harm a male fetus; no blood donation for 6 months after stopping.
Pregnancy
Contraindicated in pregnancy; pregnant women should not handle leaking capsules.

Common side effects

  • Decreased libido
  • Erectile difficulty
  • Reduced ejaculate volume
  • Breast tenderness

Key interactions

  • Strong CYP3A4 inhibitors raise its level

Counseling points

  • Takes months for full benefit
  • Pregnant women must not handle leaking capsules
  • Do not donate blood during therapy and for 6 months after
  • Lowers PSA readings: tell any provider ordering that test
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