← Drug quick-reference

Duloxetine

Brand: Cymbalta

SNRI antidepressantUsed for: Depression, nerve painCNS & Psychiatric
Key warning

Boxed warning: suicidal thoughts and behaviors in children, adolescents, and young adults

Common side effects

  • Nausea
  • Dry mouth
  • Drowsiness
  • Constipation
  • Dizziness

Key interactions & cautions

  • Serotonin syndrome risk with other serotonergic drugs
  • Avoid combining with MAO inhibitors
  • Increased bleeding risk with NSAIDs or blood thinners
  • Limit alcohol due to liver risk

Counseling points

  • Do not stop suddenly; taper as directed
  • May take a few weeks to work fully
  • Swallow capsule whole; do not crush
  • Report worsening mood or suicidal thoughts
  • Rise slowly to reduce dizziness

High-yield study aid for exam prep — not a substitute for the package insert or a pharmacist’s dispensing reference.