Cyclobenzaprine
Brand: Flexeril (discontinued; Amrix ER still marketed)
No boxed warning on the current FDA label.
- Caution
- Contraindicated with MAO inhibitors, in the recovery phase of a heart attack, and with arrhythmias; strongly anticholinergic in older adults.
Common side effects
- Drowsiness
- Dry mouth
- Dizziness
- Fatigue
Key interactions
- Do not combine with MAOI antidepressants
- Alcohol increases sedation
- Adds to other sedating drugs
- Serotonin syndrome risk with some antidepressants
Counseling points
- Best for short-term use
- Avoid alcohol
- Do not drive until you know its effect
- Intended alongside rest and physical therapy
- Rise slowly to reduce dizziness
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High-yield study aid for exam prep, not a substitute for the package insert or a pharmacist’s dispensing reference.