Colchicine
Brand: Colcrys
No boxed warning on the current FDA label.
- Caution
- Fatal overdoses have occurred; contraindicated with strong CYP3A4 or P-gp inhibitors in kidney or liver impairment.
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Abdominal cramping
Key interactions
- Grapefruit juice raises drug levels
- Certain antibiotics and antifungals raise toxicity
- Some statins increase muscle-damage risk
Counseling points
- Take at first sign of a gout flare
- Stop and call if severe diarrhea occurs
- Avoid grapefruit juice
- Do not exceed prescribed dose
- Report muscle pain or weakness
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