Clarithromycin
Brand: Biaxin (discontinued)
No boxed warning on the current FDA label.
- Caution
- QT prolongation and many CYP3A4 interactions; contraindicated with simvastatin, lovastatin, and certain ergot drugs.
- Storage
- Reconstituted suspension: room temperature (do not refrigerate, it thickens), discard after 14 days.
- Pregnancy
- Avoid in pregnancy unless no alternative: adverse outcomes in animal studies.
Common side effects
- Diarrhea
- Nausea
- Abnormal or metallic taste
- Stomach upset
- Headache
Key interactions
- Raises statin levels (avoid simvastatin)
- Many CYP3A4 interactions raise drug levels
- Can prolong QT with other QT drugs
- Increases warfarin bleeding risk
Counseling points
- Finish the full course
- May be taken with or without food
- Report irregular heartbeat or fainting
- Report severe or watery diarrhea
- Space from antacids if directed
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