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Buspirone

Brand: (BuSpar discontinued; generic only)

Anxiolytic (azapirone)Used for: Generalized anxietyCNS & Psychiatric

No boxed warning on the current FDA label.

Caution
Contraindicated with MAO inhibitors; takes 2 to 4 weeks to work and is not for as-needed use.

Common side effects

  • Dizziness
  • Headache
  • Nausea
  • Restlessness

Key interactions

  • Grapefruit juice raises its level
  • Contraindicated with MAO inhibitors
  • Additive serotonin effects

Counseling points

  • Takes 2 to 4 weeks for full effect. It is not an as-needed drug
  • No dependence or withdrawal, unlike benzodiazepines
  • Take consistently with or without food
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