Bupropion
Brand: Wellbutrin SR, Wellbutrin XL
Boxed warning
Suicidal thoughts and behaviors in children, adolescents, and young adults.
- Caution
- Lowers the seizure threshold: contraindicated with a seizure disorder, eating disorder, or abrupt alcohol or sedative withdrawal.
Common side effects
- Insomnia
- Dry mouth
- Headache
- Weight loss
- Agitation
Key interactions
- Lowers seizure threshold with certain drugs
- Avoid MAO inhibitors
- Avoid abrupt alcohol reduction
- Caution with other bupropion products
Counseling points
- Take earlier in day to reduce insomnia
- Do not crush extended-release tablets
- Avoid if history of seizures or eating disorder
- Report worsening mood or suicidal thoughts
- Do not double up with smoking-cessation versions
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