← Drug quick-reference

Meloxicam

Brand: Mobic (discontinued)

NSAIDUsed for: Osteoarthritis and rheumatoid arthritisPain & Inflammation
Boxed warning

Serious cardiovascular thrombotic events (heart attack and stroke) and serious GI bleeding, ulceration, and perforation; contraindicated for pain around CABG surgery (prescription labeling).

Caution
GI bleeding, cardiovascular thrombotic events, and kidney injury risk as with all NSAIDs; avoid around CABG surgery.
Pregnancy
Avoid from 20 weeks on: fetal kidney problems and low amniotic fluid, and ductus arteriosus closure after 30 weeks.

Common side effects

  • Stomach upset
  • Ulcers and bleeding
  • Swelling
  • High blood pressure

Key interactions

  • Blunts the effect of ACE inhibitors and diuretics
  • Additive bleeding risk with anticoagulants
  • Do not combine with other NSAIDs

Counseling points

  • Usually taken once daily
  • Take with food
  • Report black stools or persistent stomach pain
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