Lorazepam
Brand: Ativan
Boxed warning · ISMP high-alert drug
Profound sedation, respiratory depression, coma, and death when combined with opioids; abuse, misuse, addiction, and withdrawal reactions on abrupt stopping.
- Caution
- Falls and confusion in older adults; respiratory depression with other CNS depressants.
- Storage
- Injection and oral concentrate require refrigeration; tablets at room temperature.
- Pregnancy
- Avoid if possible: neonatal sedation and withdrawal, especially with late-pregnancy use.
Common side effects
- Drowsiness
- Dizziness
- Unsteadiness
- Confusion
Key interactions
- Dangerous sedation with opioids
- Adds to alcohol and other sedatives
- Avoid combining with other CNS depressants
Counseling points
- May impair driving until you know its effect
- Avoid alcohol
- Do not stop suddenly
- Controlled substance, do not share
- Rise slowly to reduce falls
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High-yield study aid for exam prep, not a substitute for the package insert or a pharmacist’s dispensing reference.