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Idarucizumab

Brand: Praxbind

Monoclonal antibody reversal agentUsed for: Reversal of dabigatranOther High-Yield

No boxed warning on the current FDA label.

Caution
Thrombotic risk returns once dabigatran is reversed; 5 g dose given as two consecutive 2.5 g vials.
Storage
Refrigerate vials (36 to 46 F); do not freeze, protect from light; once at room temperature use within 48 hours.

Common side effects

  • Headache
  • Low potassium
  • Constipation
  • Fever

Key interactions

  • Specific to dabigatran; does not reverse apixaban or rivaroxaban

Counseling points

  • Given intravenously in an emergency setting
  • Clotting risk returns once dabigatran is reversed
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