Esomeprazole
Brand: Nexium
No boxed warning on the current FDA label.
- Caution
- Long-term use is linked to C. difficile infection, low magnesium, B12 deficiency, and fractures; reduces clopidogrel activation.
Common side effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Gas
Key interactions
- May reduce clopidogrel activation
- Can lower absorption of certain drugs needing acid
- May affect some HIV medications
Counseling points
- Take at least 1 hour before a meal
- Swallow capsule whole; do not crush
- Use for the shortest effective time
- Report black stools or trouble swallowing
- Long-term use may lower magnesium or B12
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