Diltiazem
Brand: Cardizem
No boxed warning on the current FDA label.
- Caution
- Can worsen heart failure and heart block; contraindicated in sick sinus syndrome or second- or third-degree block without a pacemaker.
Common side effects
- Swelling of ankles or feet
- Dizziness
- Slow heart rate
- Constipation
- Headache
Key interactions
- Adds to heart slowing with beta-blockers
- Grapefruit juice raises drug levels
- May raise statin levels (simvastatin)
- Caution with other blood pressure drugs
Counseling points
- Take at the same time each day
- Do not crush extended-release tablets
- Rise slowly to reduce dizziness
- Report swelling, fainting, or very slow pulse
- Avoid grapefruit juice
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