Carbidopa/levodopa
Brand: Sinemet, Rytary
No boxed warning on the current FDA label.
- Caution
- Sudden sleep episodes, hallucinations, and impulse-control problems; contraindicated with non-selective MAO inhibitors.
Common side effects
- Nausea
- Involuntary movements (dyskinesia)
- Low blood pressure on standing
- Darkened sweat or urine
Key interactions
- High-protein meals reduce levodopa absorption
- Non-selective MAO inhibitors are contraindicated
- Antipsychotics oppose its effect
Counseling points
- Rise slowly: blood pressure can drop
- Darkened sweat, saliva, or urine is harmless
- Do not stop abruptly
- Take consistently relative to meals
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