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Azithromycin

Brand: Zithromax (Z-Pak)

Macrolide antibioticUsed for: Bacterial infectionsAnti-Infectives

No boxed warning on the current FDA label.

Caution
QT prolongation and fatal arrhythmias in at-risk patients; liver injury.
Storage
Reconstituted multi-dose suspension: room temperature or refrigerated, discard after 10 days; the 1 g single-dose packet is mixed in 2 oz of water and taken immediately.

Common side effects

  • Diarrhea
  • Nausea
  • Abdominal pain
  • Vomiting

Key interactions

  • Antacids with aluminum or magnesium reduce absorption
  • May add to QT-prolonging drugs
  • Can increase warfarin effect

Counseling points

  • Finish the full course as directed
  • Separate from antacids by a couple hours
  • Report irregular or fast heartbeat
  • Report severe or watery diarrhea
  • May be taken with or without food
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