Alprazolam
Brand: Xanax
Boxed warning
Profound sedation, respiratory depression, coma, and death when combined with opioids; abuse, misuse, addiction, and withdrawal reactions on abrupt stopping.
- Caution
- Short half-life makes rebound anxiety and withdrawal seizures more likely on abrupt stopping.
- Pregnancy
- Avoid if possible: neonatal sedation and withdrawal, especially with late-pregnancy use.
Common side effects
- Drowsiness
- Dizziness
- Impaired coordination
- Memory problems
- Fatigue
Key interactions
- Avoid alcohol and other sedatives
- Opioids cause dangerous sedation
- Grapefruit juice raises drug levels
- Strong CYP3A4 inhibitors raise levels
Counseling points
- Do not drive until you know its effect
- Do not stop suddenly to avoid withdrawal
- Avoid alcohol
- Use is meant to be short-term
- May be habit-forming
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