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Alprazolam

Brand: Xanax

Benzodiazepine (C-IV)Used for: AnxietyCNS & Psychiatric
Boxed warning

Profound sedation, respiratory depression, coma, and death when combined with opioids; abuse, misuse, addiction, and withdrawal reactions on abrupt stopping.

Caution
Short half-life makes rebound anxiety and withdrawal seizures more likely on abrupt stopping.
Pregnancy
Avoid if possible: neonatal sedation and withdrawal, especially with late-pregnancy use.

Common side effects

  • Drowsiness
  • Dizziness
  • Impaired coordination
  • Memory problems
  • Fatigue

Key interactions

  • Avoid alcohol and other sedatives
  • Opioids cause dangerous sedation
  • Grapefruit juice raises drug levels
  • Strong CYP3A4 inhibitors raise levels

Counseling points

  • Do not drive until you know its effect
  • Do not stop suddenly to avoid withdrawal
  • Avoid alcohol
  • Use is meant to be short-term
  • May be habit-forming
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